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KMID : 0861020070220020137
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Korea Journal of Herbology
2007 Volume.22 No. 2 p.137 ~ p.146
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Antistress effects of Lycii Radicis Cortex in the passive avoidance test and the forced swimming test
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Koh Dong-Kyun
Lee Tae-Hee
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Abstract
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Objectives : Investigation of the anitstress effects of Lycii Radicis Cortex.
Methods : Behavior was measured in PAT and FST after applying stress to rats. Also, TH expression-degree in the regions of VTA and LC was measured, respectively.
Results : The memory was improved in the LH 50mg/kg treated group in the passive avoidance test(P<0.01). The duration of immobility in the forced swimming test was significantly decreased in the LR 50mg/kg and 400mg/kg treated groups(P<0.0l). Stress-induced TH increases were meaningfully suppressed in the LR 100mg/kg and 400mg/kg treated group(P<0.001).
Conclusion : Lycii Radicis Cortes has the effect of memory improving and antidepressant.
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KEYWORD
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Lycii Radicis Cortex, PAT, FST, TH(tyrosine hydroxylase), LC, VTA
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